The strategy of "Control from Root Design" is established in Topharman. Considering safety, green, simple operation and cost, we design the synthetic route and develop the manufacturing process to provide the products in stable quality.
Early Stage Process Development
Design of new synthetic route
Process optimization for commercialization production
CPP assessment based on QbD
Establishment of Control strategies for KSMs, INTs and APIs
Process Safety Assessment
Production at Kilo lab and GMP plant including low temperature (-70oC), high temperature (250oC) and high pressure (hydrogenation) reactions